Publications

18. Injectable Microparticle-Nanoliposome Hydrogel for Extended Release of Small Hydrophilic Molecules

G. Aizik†, W. Choi†, C. A. Ostertag-Hill, M. Torre, D. S. Kohane*

ACS Nano., 2025, 19, 36342-36352

DOI: 10.1021/acsnano.5c09484

17. Proteomimetic Polymer Blocks Mitochondrial Damage, Rescues Huntington`s Neurons, and Slows Onset of Neuropathology In Vivo

W. Choi†, M. Fattah†, Y. Shang†, M. P. Thompson, K. P. Carrow, D. Hu, Z. Liu, M. M. J. Avram, K. Bailey, O. Berger, X. Qi*, N.C. Gianneschi*

Science Advances., 2024, 10 (44), eado8307.

DOI: 10.1126/sciadv.ado830

16. Hybrid Nanoparticle – Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications

W. Choi, D. S. Kohane*

ACS Nano., 2024, 18, 22780-22797.

DOI: 10.1021/acsnano.4c06888

15. Injectable Hydrogel Based on Liposome Self-Assembly for Controlled Release of Small Hydrophilic Molecules

G. Aizik, C. A. Ostertag-Hill, P. Chakraborty, W. Choi, M. Pan, D. V. Mankus, A. K. R. Lytton-Jean, D. S. Kohane*

Acta Biomater., 2024, 183, 101-110.

DOI: 10.1016/j.actbio.2024.05.044

14. Long-Circulating Vasoactive 1,18-Octadecanedioic Acid-Terlipression Conjugate

O. Berger, W. Choi, C. H. Ko, M. P. Thompson, M. J. Avram, D. J. Scott, B. L. Hoare, R. Cridge, M. Wheatly, R. A. Bathgate, D. Batlle, N. C. Gianneschi*

ACS Pharmacol.Transl. Sci., 2024, 7, 5, 1252-1261.

DOI: 10.1021/acsptsci.3c00305

13. A Hybrid Nanoparticle-Protein Hydrogel for Prolonged Local Anesthesia

W. Choi, G. Aizik, C. A. Ostertag-Hill, D. S. Kohane*

Biomaterials., 2024, 306. 122494.

DOI: 10.1016/j.biomaterials.2024.122494

12. Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model

W. Choi†, A. K. Nensel†, S. Droho, M. A. Fattah, S. M-Punekar, D. I. Swygart, S. T. Burton, G. W. Schwartz*, J. A. Lavine*, N.C. Gianneschi*.

Science Advances., 2023, 9 (41), eadi8534.

DOI: 10.1126/sciadv.adi8534

acscii.2021.7.issue-12.largecover-2 (1).jpg

11. Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics

H. Sun†, B. Qiao†, W. Choi†, N. Hampu, N. C. McCallum, M. P. Thompson, J. Oktawiec, S. Weigand, O. M. Ebrahim, M. O. de la Cruz*, N.C. Gianneschi*

ACS Cent. Sci., 2021, 7, 12, 2063-2072.

DOI: 10.1021/acscentsci.1c01149

10. pH-Responsive Charge-Conversion Progelator Peptides

A. S. Carlini*, W. Choi, N. C. McCallum, N. C. Gianneschi*

Advanced Functional Materials., 2021, 31, 2007733.

DOI: 10.1002/adfm.202007733

9. High Efficiency Loading of Micellar Nanoparticles with a Light Switch for Enzyme- Induced Rapid Release of Cargo

W. Choi†, C. Battistella†, N. C. Gianneschi*

Biomaterials Science, 2021, 9, 653-657.

DOI: 10.1039/D0BM01713B

8. Biomolecular Densely Grafted Brush Polymers: Oligonucleotides, Oligosaccharides and Oligopeptides

W. Choi, H. Sun, C. Battistella, O. Berger, M. A. Vratsanos, M. M. Wang, N. C. Gianneschi*

Angew. Chem. Int. Ed., 2020, 59, 2-13.

DOI: 10.1002/anie.202005379

7. Proapoptotic Peptide Brush Polymer Nanoparticles via Photoinitiated Polymerization- Induced Self-Assembly

H. Sun†, W. Cao†, N. Zang†, T. D. Clemons, G. M. Scheutz, Z. Hu, M. P. Thompson, Y. Liang, M. A. Vratsanos, X. Zhou, W. Choi, B. S. Sumerlin, S. I. Stupp, N. C. Gianneschi*

Angew. Chem. Int. Ed., 2020, 59, 2-9.

DOI: 10.1002/anie.202006385

6. Bioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical Polymerization.

H. Sun†, W. Choi†, N. Zang, C. Battistella, M. P. Thompson, W. Cao, X. Zhou, C. Forman, N. C. Gianneschi*

Angew. Chem. Int. Ed., 2019, 58, 17359-17364.

DOI: 10.1126/sciadv.adi8534

5. Recent Advances in Amphiphilic Polymer Oligonucleotide Nanomaterials via Living/Controlled Polymerization Technologies. Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age related macular degeneration mouse model

H. Sun, L. Yang, M. P. Thompson, S. Schara, W. Cao, W. Choi, Z. Hu, N. Zang, W. Tan*, N. C. Gianneschi*

Bioconjugate Chemistry, 2019, 30, 1889-1904.

DOI: 10.1021/acs.bioconjchem.9b00166

4. A strategy for the separation of diterpenoid isomers from the root of Aralia continentalis by countercurrent chromatography: The distribution ratio as a substitute for the partition coefficient and a three- phase solvent system

K. J. Lee, K. H. Song, W. Choi, Y. S. Kim*

Journal of Chromatography A. 2015, 224-230

DOI: 10.1016/j.chroma.2015.06.038

3. Unlocking the pH-Responsive Degradability of Fumaramic Acid Derivatives Using Photoisomerization

W. Choi, S. Kang, Y. Mok, E. Park, Y. Song, S. J. Choi, Y. Lee*

Chemistry-A European Journal, 2014, 20, 15715-15718.

DOI: 10.1002/chem.201405205

2. Comparison of pH-sensitive degradability of maleic acid amide derivatives

S. Kang, Y. Kim, Y. Song, J. U. Choi, E. Park, W. Choi, J. Park, Y. Lee*

Bioorganic & Medicinal Chemistry Letters, 2014, 24, 2364-2367.

DOI: 10.1016/j.bmcl.2014.03.057

1. Synthesis of biomembrane-mimic polymers with various phospholipid head groups

H. Kim, W. Choi, S. Lee, S. Kim, J. Ham, J. H. Seo, S. Jang, Y. Lee*

Polymer, 2014, 55, 517-524.

DOI: 10.1016/j.polymer.2013.12.020